Kalipada Pahan Selected Research

Proteins (Proteins, Gene)

1/2023	Treadmill workout activates PPARα in the hippocampus to upregulate ADAM10, decrease plaques and improve cognitive functions in 5XFAD mouse model of Alzheimer's disease.
2/2016	BPOZ-2 Gene Delivery Ameliorates Alpha-Synucleinopathy in A53T Transgenic Mouse Model of Parkinson's Disease.
7/2015	Activation of peroxisome proliferator-activated receptor α stimulates ADAM10-mediated proteolysis of APP.
9/2014	Cinnamon treatment upregulates neuroprotective proteins Parkin and DJ-1 and protects dopaminergic neurons in a mouse model of Parkinson's disease.
1/2014	Enhancement of morphological plasticity in hippocampal neurons by a physically modified saline via phosphatidylinositol-3 kinase.
1/2014	A physically-modified saline suppresses neuronal apoptosis, attenuates tau phosphorylation and protects memory in an animal model of Alzheimer's disease.
6/2012	Sodium benzoate, a metabolite of cinnamon and a food additive, upregulates neuroprotective Parkinson disease protein DJ-1 in astrocytes and neurons.

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Kalipada Pahan Research Topics

Disease

30	Multiple Sclerosis 05/2024 - 10/2002
24	Inflammation (Inflammations) 03/2024 - 05/2006
23	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 12/2023 - 04/2003
23	Parkinson Disease (Parkinson's Disease) 09/2023 - 11/2007
22	Neurodegenerative Diseases (Neurodegenerative Disease) 03/2024 - 07/2006
16	Alzheimer Disease (Alzheimer's Disease) 01/2023 - 11/2008
11	Inborn Urea Cycle Disorders 03/2022 - 04/2003
10	Neuroinflammatory Diseases 04/2024 - 11/2002
10	Demyelinating Diseases (Demyelinating Disease) 11/2018 - 07/2006
6	Neuronal Ceroid-Lipofuscinoses (Neuronal Ceroid Lipofuscinosis) 03/2024 - 11/2012
6	Amyloid Plaque 01/2023 - 01/2014
6	Nonketotic Hyperglycinemia 03/2022 - 01/2020
5	Huntington Disease (Huntington's Disease) 03/2024 - 01/2016
5	Neoplasms (Cancer) 12/2023 - 02/2016
4	Pain (Aches) 03/2024 - 12/2013
4	COVID-19 01/2023 - 01/2021
4	Dementia (Dementias) 10/2021 - 09/2003
4	Autoimmune Diseases (Autoimmune Disease) 01/2021 - 10/2002
4	Disease Progression 05/2017 - 07/2007
3	Gliosis 01/2023 - 05/2006
3	Fever (Fevers) 01/2023 - 01/2021
3	Vesicular Stomatitis 01/2023 - 11/2021
3	Hyperlipidemias (Hyperlipidemia) 05/2019 - 10/2007
2	Tay-Sachs Disease 03/2024 - 12/2023
2	Traumatic Brain Injuries (Traumatic Brain Injury) 01/2023 - 01/2020
2	Pneumonia (Pneumonitis) 01/2023 - 12/2021
2	Rheumatoid Arthritis 01/2023 - 02/2010
2	Synucleinopathies 12/2022 - 05/2019
2	Murine Acquired Immunodeficiency Syndrome (MAIDS) 11/2022 - 01/2021
2	Parkinsonian Disorders (Parkinsonism) 03/2022 - 11/2007
2	Infections 01/2021 - 10/2017
2	Hyperammonemia 01/2019 - 03/2013
2	Chronic Disease (Chronic Diseases) 11/2018 - 05/2017
2	Virus Diseases (Viral Diseases) 06/2008 - 04/2004
1	Sandhoff Disease (Sandhoff's Disease) 03/2024
1	Heartburn (Pyrosis) 03/2024
1	Pancreatic Neoplasms (Pancreatic Cancer) 12/2023

Drug/Important Bio-Agent (IBA)

14	Sodium Benzoate FDA Link 03/2022 - 07/2007
13	Gemfibrozil (Lopid)FDA LinkGeneric 12/2023 - 11/2002
10	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 03/2024 - 06/2013
10	LipidsIBA 12/2023 - 10/2007
9	Interleukin-23 (Interleukin 23)IBA 05/2024 - 06/2008
9	Peptides (Polypeptides)IBA 01/2023 - 07/2004
8	Interleukin-12 (IL 12)IBA 05/2024 - 06/2008
8	CytokinesIBA 05/2024 - 09/2005
8	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 12/2023 - 08/2012
8	RNS60IBA 01/2020 - 01/2012
7	Proteins (Proteins, Gene)FDA Link 01/2023 - 06/2012
7	Food Additives (Food Additive)IBA 03/2022 - 07/2007
6	Amyloid (Amyloid Fibrils)IBA 01/2023 - 01/2014
5	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2023 - 07/2006
5	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 03/2022 - 11/2007
5	Therapeutic UsesIBA 10/2021 - 11/2002
5	Myelin Basic ProteinIBA 11/2018 - 09/2005
4	LigandsIBA 03/2024 - 03/2015
4	Tripeptidyl-Peptidase 1IBA 03/2024 - 11/2012
4	cinnamic acidIBA 03/2024 - 01/2018
4	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 09/2023 - 04/2004
4	Angiotensin-Converting Enzyme 2IBA 01/2023 - 01/2021
4	Chemokine CCL5IBA 12/2019 - 01/2016
3	Interleukin-12 Subunit p40IBA 12/2023 - 04/2009
3	EnzymesIBA 12/2023 - 01/2017
3	Transcription Factors (Transcription Factor)IBA 01/2023 - 08/2012
3	Amyloid beta-PeptidesIBA 01/2019 - 11/2008
3	4-phenylbutyric acid (Buphenyl)FDA Link 03/2013 - 04/2003
3	NF-kappa B (NF-kB)IBA 11/2007 - 11/2002
2	Interleukin-2 (IL2)IBA 05/2024 - 12/2023
2	Butyrates (Butyrate)IBA 03/2024 - 01/2019
2	GangliosidesIBA 03/2024 - 12/2023
2	G(M2) Ganglioside (Ganglioside GM2)IBA 03/2024 - 12/2023
2	GlycoconjugatesIBA 03/2024 - 12/2023
2	Fenofibrate (CiL)FDA LinkGeneric 12/2022 - 11/2012
2	glyceryl tribenzoateIBA 03/2022 - 02/2017
2	Monoclonal AntibodiesIBA 01/2022 - 04/2009
2	Glial Cell Line-Derived Neurotrophic Factor (GDNF)IBA 10/2021 - 01/2019
2	Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link 01/2021 - 07/2012
2	alpha-SynucleinIBA 02/2016 - 11/2013
2	Ciliary Neurotrophic Factor (CNTF)IBA 11/2015 - 06/2013
2	Simvastatin (Zocor)FDA LinkGeneric 08/2015 - 10/2009
2	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 08/2015 - 06/2011
2	Brain-Derived Neurotrophic Factor (BDNF)IBA 06/2013 - 03/2013
2	Nerve Growth Factors (Neurotrophins)IBA 06/2013 - 03/2013
2	Phosphotransferases (Kinase)IBA 09/2012 - 11/2007
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2012 - 09/2008
2	Sphingomyelin Phosphodiesterase (Sphingomyelinase)IBA 09/2010 - 06/2007
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 08/2009 - 09/2003
2	Double-Stranded RNA (RNA, Double Stranded)IBA 06/2008 - 04/2004
2	I-kappa B KinaseIBA 11/2007 - 07/2004
2	Drinking WaterIBA 07/2007 - 04/2003
2	AntigensIBA 06/2003 - 10/2002
1	benzyl cinnamateIBA 04/2024
1	Biomarkers (Surrogate Marker)IBA 12/2023
1	Hexosaminidases (Hexosaminidase)IBA 12/2023
1	LipopolysaccharidesIBA 09/2023
1	Indicators and Reagents (Reagents)IBA 09/2023

Therapy/Procedure

18	Therapeutics 03/2024 - 12/2007
7	Oral Administration 03/2024 - 01/2015
3	Intranasal Administration 01/2023 - 10/2021
3	Immunomodulation 01/2020 - 12/2011
2	Immunotherapy 12/2023 - 01/2022